https://ogma.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52405 Wed 28 Feb 2024 15:54:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:52384 Wed 28 Feb 2024 15:35:45 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46408 P < 0.001). An increase of one fast-food outlet corresponded with four additional cases of MI per 100 000 people per year (4.07, 95% confidence interval, 3.86-4.28). Conclusions: FFD was positively associated with incidence of MI in both rural and metropolitan areas of NSW. This relationship remained consistent after multivariate adjustment for standard cardiovascular risk factors, highlighting the importance of an individual's food environment as a potential contributor towards their health.]]> Wed 28 Feb 2024 14:47:00 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:45064 Wed 26 Oct 2022 11:42:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34918 Wed 24 Nov 2021 15:53:19 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:19339  A, −1.0 years per allele, p = 0.042; rs35652124 A > G, −1.1 years per allele, p = 0.045; rs2886161 A > G, −1.2 years per allele, p = 0.021; rs1806649 G > A, +1.2 years per allele, p = 0.029). One of these (rs35652124) is a functional SNP located in the NFE2L2 promoter. No individual SNP was associated with risk of Parkinson’s disease. Conclusion: Our results support the hypothesis that variation in the NFE2L2 gene, encoding a central protein in the cellular protection against oxidative stress, may contribute to the pathogenesis of Parkinson’s disease. Functional studies are now needed to explore these results further.]]> Wed 11 Apr 2018 14:07:28 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4567 Wed 11 Apr 2018 10:36:33 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:13381 Wed 11 Apr 2018 09:54:43 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:18227 Wed 11 Apr 2018 09:14:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:39240 h2 signalling, improved their outcomes. Methods: Male BALB/c mice were intranasally sensitized with house dust mite antigen (Der p 1) for 2 weeks; the mice were then inoculated intranasally with a single dose of pandemic H1N1 (pH1N1). The mice were administered intraperitoneally anti-IL-4Rα through either a prophylactic or a therapeutic treatment strategy. Results: Infection with pH1N1 of mice sensitized to house dust mite (HDM) led to a 24% loss in weight by day 7 of infection (versus 14% in non-sensitized mice; p < .05). This was accompanied by increased viral load in the airways and a dampened anti-viral host responses to the infection. Treatment of HDM sensitized mice with a monoclonal antibody against IL-4Rα prior to or following pH1N1 infection prevented the excess weight loss, reduced the viral load in the lungs and ameliorated airway eosinophilia and systemic inflammation related to the pH1N1 infection. Conclusion: Together, these data implicate allergic asthma as a significant risk factor for H1N1-related morbidity and reveal a potential therapeutic role for IL-4Rα signalling blockade in reducing the severity of influenza infection in those with allergic airway disease.]]> Wed 10 Aug 2022 08:53:16 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48956 Tue 18 Apr 2023 15:35:05 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:24617 Thu 17 Feb 2022 09:26:56 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:34413 Thu 04 Nov 2021 10:38:35 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:41461 TP53 vary depending on the subtype, such that ER-negative tumours have a high rate, and in ER-positive tumours they are less common. Previous studies have implicated the intronic polymorphism in TP53 (rs17878362; or PIN3) with an increased risk of developing breast cancer, although little has been discerned on its prevalence in different subtypes. In this study, we investigated the prevalence of the PIN3 genotype in the blood of cohorts with ER-positive and the ER-negative subtype TNBC, and assessed its association with outcome. Methods: We genotyped 656 TNBC and 648 ER-positive breast cancer patients, along with 436 controls, and compared the prevalence of polymorphism rs17878362 in these cohorts. Results: We found there to be no differences in the prevalence of the PIN3 genotype between the ER-positive and TNBC cohorts. Furthermore, no statistically significant difference was observed in the outcome of patients in either cohort with respect to their PIN3 genotype. Conclusions: Taken together, our results do not support an association of the PIN3 genotype with increased breast cancer risk, either in ER-positive or ER-negative patients.]]> Thu 01 Sep 2022 11:19:24 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:31404 versus good OH on periodontitis across studies. The associations between oral care habits and periodontitis were also assessed. Results: A total of 50 studies were eligible; 15 were used for pooling the effect of fair OH versus good OH and poor OH versus good OH on periodontitis, with pooled odds ratios (ORs) of 2.04 [95% confidence interval (CI): 1.65-2.53] and 5.01 (95% CI: 3.40-7.39), respectively. Eleven studies examined oral care habits measured according to toothbrushing regularity and dental visit frequency; pooled ORs of 0.66 (95% CI: 0.47-0.94) and 0.68 (95% CI: 0.47-0.98) were obtained, respectively. Conclusions: Fair to poor OH increases the risk of periodontitis by two- to five-fold. This risk can be reduced by regular toothbrushing and dental visits.]]> Sat 24 Mar 2018 08:45:15 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:8227 Sat 24 Mar 2018 08:40:40 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:7670 Sat 24 Mar 2018 08:39:25 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:21100 Sat 24 Mar 2018 07:53:58 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:357 Sat 24 Mar 2018 07:42:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28285 Necator americanus being most common (60%; 95% Confidence Interval 58-62%) followed by Ascaris spp. (24%; 95% Confidence Interval 23-26%). Ascaris-N. americanus co-infection was common (17%; 95% Confidence Interval 15%-18%). Giardia duodenalis was the main protozoan identified (13%; 95% Confidence Interval 11-14%). Baseline water, sanitation and hygiene infrastructure and behaviours were poor. Although risk factors varied by age of participants and parasite species, risk factors for N. americanus infection included, generally, age in years, male sex, and socioeconomic quintile. Risk factors for Ascaris included age in years for children, and piped water to the yard for adults. In this first known assessment of community-based prevalence and associated risk factors in Timor-Leste, soil transmitted helminth infections were highly prevalent, indicating a need for soil transmitted helminth control. Few associations with water, sanitation and hygiene were evident, despite water, sanitation and hygiene being generally poor. In our water, sanitation and hygiene we will investigate implications of improving WASH on soil transmitted helminth infection in impoverished communities.]]> Sat 24 Mar 2018 07:41:23 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:28439 75th percentile (≥43 µg/l) (OR 1.49, 95 % CI 1.06, 2.10) and >90th percentile (≥68 µg/l) (OR 1.92, 95 % CI 1.25, 2.96). Increased odds of early and moderate-to-late sPTB were associated with ferritin levels >90th percentile (OR 2.50, 95 % CI 1.32, 4.73) and >75th percentile (OR 1.56, 95 % CI 1.03, 2.37), respectively. No association was found between the risk of sPTB and elevated sTfR levels or Fe deficiency. In conclusion, elevated maternal serum ferritin levels in early pregnancy are associated with an increased risk of sPTB from 34 weeks of gestation. The usefulness of early pregnancy ferritin levels in identifying women at risk of sPTB warrants further investigation.]]> Sat 24 Mar 2018 07:29:04 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:4920 Sat 24 Mar 2018 07:21:12 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:23509 Sat 24 Mar 2018 07:17:18 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:38383 Mon 29 Jan 2024 17:45:07 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:46667 International Statistical Classification of Diseases and Related Health Problems (Tenth Edition, Australian Modification) codes from the hospital admissions and emergency presentation data. The outcome variable and other system factors were derived from the Australian Stroke Clinical Registry dataset. Multivariable, multilevel logistic regression was used to examine factors associated with the prescription of antihypertensive medications at hospital discharge. Results: Of the 10 315 patients included, 79.0% (intracerebral hemorrhage, 74.1%; acute ischemic stroke, 79.8%) were prescribed antihypertensive medications at discharge. Prescription varied between hospital sites, with 6 sites >2 SDs below the national average for provision of antihypertensives at discharge. Prescription was also independently associated with patient and clinical factors including history of hypertension, diabetes mellitus, management in an acute stroke unit, and discharge to rehabilitation. In patients with acute ischemic stroke, females (odds ratio, 0.85; 95% CI, 0.76-0.94), those who had greater stroke severity (odds ratio, 0.81; 95% CI 0.72-0.92), or dementia (odds ratio, 0.65; 95% CI, 0.52-0.81) were less likely to be prescribed. Conclusions: Prescription of antihypertensive medications poststroke varies between hospitals and according to patient factors including age, sex, stroke severity, and comorbidity profile. Implementation of targeted quality improvement initiatives at local hospitals may help to reduce the variation in prescription observed.]]> Mon 28 Nov 2022 18:46:24 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:44756 Mon 24 Oct 2022 08:42:37 AEDT ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:42033 Drosophila RNAi-knockdowns, we observed a significant increase in the total body triglyceride levels for two genes (DNAH10 and PLXND1). We implicate novel genes in fat distribution, stressing the importance of interrogating low-frequency and protein-coding variants.]]> Mon 22 Aug 2022 10:16:20 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51789 Mon 18 Sep 2023 15:18:25 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:50981 Mon 14 Aug 2023 15:39:12 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:48230 Mon 08 May 2023 10:28:01 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:51721 Fri 15 Sep 2023 17:53:07 AEST ]]> https://ogma.newcastle.edu.au/vital/access/ /manager/Repository/uon:49881 Fri 09 Jun 2023 10:36:37 AEST ]]>